M16. PROFILING GLUTAMATE AND D-SERINE PATHWAYS IN TREATMENT RESISTANT EARLY PSYCHOSIS PATIENTS
نویسندگان
چکیده
منابع مشابه
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.
Although D amino acids are prominent in bacteria, they generally are thought not to occur in mammals. Recently, high levels of D-serine have been found in mammalian brain where it activates glutamate/N-methyl-D-aspartate receptors by interacting with the "glycine site" of the receptor. Because amino acid racemases are thought to be restricted to bacteria and insects, the origin of D-serine in m...
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*Biostructural Research Unit, Department of Medicinal Chemistry, and §Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; †Department of Molecular Neurobiology, Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark; and ‡Department of Pharmacology, Emory University School of Medicine, 1510 ...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2020
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbaa030.328